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The Effects of Endocrine Disruptors on Steroidogenesis Gene Expression Dynamics in Fathead Minnow
Citation:
VINAS, R., N. G, X. GUAN, D. L. VILLENEUVE, D. MARTINOVIC, S. M. BRASFIELD, L. S. BLAKE, J. D. BRODIN, J. SHOEMAKER, N. D. DENSLOW, G. T. ANKLEY, G. J. DOYLE III, AND E. PERKINS. The Effects of Endocrine Disruptors on Steroidogenesis Gene Expression Dynamics in Fathead Minnow. Presented at SETAC Europe, 18th Annual Meeting, Warsaw, POLAND, May 25 - 29, 2008.
Impact/Purpose:
research results
Description:
Steroid hormones play key roles in regulating reproduction and development and fish and other vertebrates. This presentation reports results from two in vitro experiments aimed characterizing the dynamics of transcriptional and metabolomic responses to endocrine disrupting chemicals (EDCs) that inhibit enzymes critical to steroid hormone synthesis. Results suggest that dynamic transcript-level responses occur within the first two hours of in vitro exposure and suggest tissue-level feedback mechanisms that mediate response to the chemical. Results contribute to on-going development of computational models to aid in predicting adverse effects of EDCs based on mode of action.