EPA Science Inventory

Fundulus as the Premier Teleost Model in Environmental Biology: Opportunities for New Insights Using Genomics

Citation:

Burnett, K. G., L. J. Bain, W. S. Baldwin, G. V. Callard, S. Cohen, R. T. Di Giulio, D. H. Evans, M. Gomez-Chiarri, M. E. Hahn, C. A. Hoover, S. Karchner, F. Katoh, D. L. MacLatchy, W. S. Marshall, J. N. Meyer, D. E. NACCI, M. F. Oleksiak, B. B. Rees, T. D. Singer, J. J. Stegeman, D. W. Towle, P. A. Van Veld, W. K. Vogelbein, A. Whitehead, R. N. Winn, AND D. L. Crawford. Fundulus as the Premier Teleost Model in Environmental Biology: Opportunities for New Insights Using Genomics. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY - PART D: GENOMICS AND PROTEOMICS. Elsevier BV, AMSTERDAM, Netherlands, 2(4):257-286, (2007).

Impact/Purpose:

This paper summarizes an extensive body of work examining the adaptive responses of a common estuarine fish species (Fundulus heteroclitus) that has served as an important research model contributing to our understanding of physiology, gene regulation, toxicology, and ecological and evolutionary genetics of teleosts and other vertebrates. This synthesis, authored by a consortium of scientists of varying disciplines and affiliations, provides support for the development of a more complete genomics toolbox for this species, which will permit researchers to exploit the power of this model organism to rapidly advance our understanding of fundamental biological and pathological mechanisms among vertebrates, as well as ecological strategies and evolutionary processes common to all living organisms.

Description:

A strong foundation of basic and applied research documents that the estuarine fish Fundulus heteroclitus and related species are unique laboratory and field models for understanding how individuals and populations interact with their environment. In this paper we summarize an extensive body of work examining the adaptive responses of Fundulus species to environmental conditions, and describe how this research has contributed importantly to our understanding of physiology, gene regulation, toxicology, and ecological and evolutionary genetics of teleosts and other vertebrates. These explorations have reached a critical juncture at which advancement is hindered by the lack of genomic resources for these species. We suggest that a more complete genomics toolbox for F. heteroclitus and related species will permit researchers to exploit the power of this model organism to rapidly advance our understanding of fundamental biological and pathological mechanisms among vertebrates, as well as ecological strategies and evolutionary processes common to all living organisms.

URLs/Downloads:

Fundulus as the Premier Teleost Model in Environmental Biology: Opportunities for New Insights Using Genomics   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 12/10/2007
Record Last Revised: 08/18/2015
OMB Category: Other
Record ID: 187204

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

ATLANTIC ECOLOGY DIVISION

POPULATION ECOLOGY BRANCH