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Predicting Age-Appropriate Pharmacokinetics of Six Volatile Organic Compounds in the Rat Utilizing Physiologically Based Pharmacokinetic Modeling
Citation:
RODRIGUEZ, C. E., D. A. Mahle, J. M. Gearhart, D. R. Mattie, J. C. LIPSCOMB, R. S. Cook, AND H. A. BARTON. Predicting Age-Appropriate Pharmacokinetics of Six Volatile Organic Compounds in the Rat Utilizing Physiologically Based Pharmacokinetic Modeling. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 98(1):43-56, (2007).
Impact/Purpose:
The capability of physiologically based pharmacokinetic models to incorporate age-appropriate physiological and chemical-specific parameters was utilized to predict changes in internal dosimetry for six volatile organic compounds (VOCs) across different ages of rats.
Description:
The capability of physiologically based pharmacokinetic models to incorporate age-appropriate physiological and chemical-specific parameters was utilized to predict changes in internal dosimetry for six volatile organic compounds (VOCs) across different ages of rats.
