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EPA's ToxCast Program for Predicting Hazard and Prioritizing the Toxicity Testing of Environmental Chemicals
Citation:
DIX, D. J. EPA's ToxCast Program for Predicting Hazard and Prioritizing the Toxicity Testing of Environmental Chemicals. Presented at Society for Risk Analysis 2007 Annual Meeting, San Antonio, TX, December 09 - 12, 2007.
Impact/Purpose:
The U.S. EPA has made a significant investment in this approach through its ToxCastTM program (www.epa.gov/comptox/toxcast), with the goal of building accurate predictive models for thousands of antimicrobials, pesticide inert ingredients, new and existing industrial chemicals, and drinking water candidate contaminants with limited toxicity data available for hazard and risk assessments.
Description:
An alternative is to perform a set of relatively inexpensive and rapid high throughput screening (HTS) assays, derive signatures predictive of effects or modes of chemical toxicity from the HTS data, then use these predictions to prioritize chemicals for more detailed analysis. The U.S. EPA has made a significant investment in this approach through its ToxCastTM program (www.epa.gov/comptox/toxcast), with the goal of building accurate predictive models for thousands of antimicrobials, pesticide inert ingredients, new and existing industrial chemicals, and drinking water candidate contaminants with limited toxicity data available for hazard and risk assessments.
URLs/Downloads:
EPAs ToxCast Program for Predicting Hazard and Prioritizing the Toxicity Testing of Environmental Chemicals (PDF, NA pp, 9 KB, about PDF)EPAs ToxCast Program for Predicting Hazard and Prioritizing the Toxicity Testing of Environmental Chemicals (slide) (PDF, NA pp, 3030 KB, about PDF)