You are here:
NEW TECHNOLOGIES TO SOLVE OLD PROBLEMS AND ADDRESS ISSUES IN RISK ASSESSMENT
Citation:
WOLF, D. C. NEW TECHNOLOGIES TO SOLVE OLD PROBLEMS AND ADDRESS ISSUES IN RISK ASSESSMENT. Presented at Latin American Society of Toxicologic Pathology annual meeting, Sao Paulo, BRAZIL, March 28 - 29, 2008.
Impact/Purpose:
The focus of this presentation will be on how new technologies may be able to help us with old problems such as cumulative risk, screening and prioritization, and identification of environmental hazards.
Description:
Appropriate utilization of data is an ongoing concern of the regulated industries and the agencies charged with assessing safety or risk. An area of current interest is the possibility that toxicogenomics will enhance our ability to develop higher or high-throughput models for predicting potential safety concerns or for rapidly identifying biomarkers of exposure or effect. These models could be developed to predict potential health concerns, prioritize testing strategies, or establish prognostic markers by helping to identify exposure to effect linkages. Although submission of toxicogenomic data that could be incorporated into such models is not required by regulation, providing registrants or other interested parties the opportunity to submit data in an organized way would enable both the regulated community and the agency to develop useful procedures for interpreting this new science. Currently, the value of this information has been in confirming biological or toxicity pathways and developing predictive models for prioritizing further testing. Establishing methods for application in safety and risk assessment are in the early stages of development. The focus of this presentation will be on how new technologies may be able to help us with old problems such as cumulative risk, screening and prioritization, and identification of environmental hazards. [This abstract has been reviewed and approved for publication but does not necessarily represent the policies or opinions of the U. S. Environmental Protection Agency.]