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IRIS Toxicological Review of Tetrahydrofuran (THF) (External Review Draft)
EPA announces the release of the Toxicological Review of Tetrahydrofuran and notice of the External Peer Review Panel Meeting in the August 20, 2007 Federal Register Notice. This draft assessment is provided for public viewing and comment. Public comments received on the Toxicological Review within the external review period (next 60 days) will be provided to the peer reviewers prior to the meeting for their consideration. Any comments not received within the requested time period will be considered by EPA in their revisions.
U.S. EPA. IRIS Toxicological Review of Tetrahydrofuran (THF) (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, NCEA-S-1620, 2007.
EPA is undertaking an Integrated Risk Information System (IRIS) health assessment for tetrahydrofuran. IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment paradigm, i.e., hazard identification and dose-response evaluation. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risk associated with environmental contaminants.
EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of tetrahydrofuran (THF) that when finalized will appear on the Integrated Risk Information System (IRIS) database.
URLs/Downloads:FR NOTICE: AUGUST 20, 2007 Exit
Consolidated Comments from the External Peer Review (Final) (PDF,58 pp, 323 KB, about PDF)
DRAFT CHARGE TO EXTERNAL REVIEWERS FOR THE TOXICOLOGICAL REVIEW OF TETRAHYDROFURAN (THF) (PDF,4 pp, 24 KB, about PDF)
TOXICOLOGICAL REVIEW OF TETRAHYDROFURAN (EXTERNAL REVIEW DRAFT) (PDF,159 pp, 1090 KB, about PDF)