Science Inventory

IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Preliminary Assessment Materials)


EPA hosted an IRIS public science meeting on December 12-13, 2013, to provide an opportunity for the public to give input and participate in an open discussion regarding preliminary materials that were prepared for the IRIS chemical, hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), prior to the development of the draft assessment.


U.S. EPA. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-13/140, 2013.


The U.S. EPA is conducting a new health assessment of RDX that will appear on the Agency's online database, the Integrated Risk Information System (IRIS). IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment process, i.e., hazard identification and dose-response evaluation. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risks associated with environmental contaminants.


In August 2013, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for RDX to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in comments on the following:

  • Draft literature search strategies
    • The approach for identifying studies
    • The screening process for selecting pertinent studies
    • The resulting list of pertinent studies
  • Preliminary evidence tables
    • The process for selecting studies to include in evidence tables
    • The quality of the studies in the evidence tables
The literature search strategy, which describes the processes for identifying scientific literature, contains the studies that EPA considered and selected to include in the evidence tables. The preliminary evidence tables and exposure-response arrays present the key study data in a standardized format. The evidence tables summarize the available critical scientific literature. The exposure-response figures provide a graphical representation of the responses at different levels of exposure for each study in the evidence table.


FR Notice: Aug 9, 2013   Exit

IRIS December Public Science Meeting -- RDX Presentations

Draft literature search and associated strategy and evidence tables for RDX   (PDF,93 pp, 1930 KB,  about PDF)

Primary Literature Search References Sorted By Author (RDX)

Record Details:

Product Published Date: 08/26/2013
Record Last Revised: 08/29/2018
OMB Category: Other
Record ID: 176619