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A STUDY OF THE INTERCONVERSION OF METHYLATED ARSENIC OXIDES TO METHYLATED ARSENIC SULFIDES IN SOLUTIONS CONTAINING FREE SULFIDE
Citation:
CONKLIN, S., P. A. CREED, AND JOHN T. CREED. A STUDY OF THE INTERCONVERSION OF METHYLATED ARSENIC OXIDES TO METHYLATED ARSENIC SULFIDES IN SOLUTIONS CONTAINING FREE SULFIDE. Presented at 2007 European Winter Conference on Plasma Spectrochemistry, Taormina, ITALY, February 18 - 23, 2007.
Description:
Evidence suggests that thiolated arsenicals are urinary metabolites in both humans and rats. These thiolated species may be formed in the digestive system or as metabolites within the body. The role they may play in the overall toxicity of arsenic is an active area of research. This research effort would benefit from an improved understanding of how the oxide and thiolated forms of arsenic can interconvert based on matrix constituents.
Data will be presented demonstrating that trimethylarsine oxide (TMAO), dimethlyarsinic acid (DMA) and monomethylarsonic acid (MMA) all produce thiolated analogs in the presence of solution phase sulfide. This conversion is shown to be pH sensitive and the conversion rate is shown to increase in the following order: MMA