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PRIONS AND THE TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES
Citation:
WIGGINS, R. C. PRIONS AND THE TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES. Edition 2, Chapter 23, Dr. David McCandless (ed.), Metabolic Encephalopathy. Springer, New York, NY, , chapter 23., (2008).
Impact/Purpose:
This book chapter is an invited, scholarly review of the mechanism(s) of TSEs for the 2nd edition of Metabolic Encephalopathies.
Description:
This book chapter is an invited, scholarly review of the mechanism(s) of TSEs for the 2nd edition of Metabolic Encephalopathies. Each chapter in the book assumes a professional knowledge of neuroscience and biochemistry, and the focus of the book is on the metabolic basis of disease, prognosis, and treatment of encephalopathies. This chapter on prions is written accordingly and places emphasis on: origin of the prion hypothesis; prion transmission; gaps in the prion concept; prion disease prevention; the mechanism of infectivity; metabolic function of the normal prion protein; mechanisms of the prion protein misfolding; progression from exposure to clinical disease; and horizontal spread of disease.
