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EXPOSURE ASSESSMENT TOOLS FOR CUMULATIVE RISK ASSESSMENT: MEASUREMENT OF ENDOGENOUS BIOMARKERS
Citation:
HUBBARD, H., J. D. PLEIL, AND M. C. MADDEN. EXPOSURE ASSESSMENT TOOLS FOR CUMULATIVE RISK ASSESSMENT: MEASUREMENT OF ENDOGENOUS BIOMARKERS. Presented at Society of Environmental Toxicology and Chemistry, Chicago, IL, March 14 - 16, 2007.
Impact/Purpose:
Objectives for this task include the following:
o Investigate the current research on biomarkers of exposure for humans (ILSI documents).
o Develop better measurement methods and procedures for collecting biomarkers of exposure in human research studies.
o Conduct advanced statistical analyses on existing urinary biomarker data generated from EPA funded studies.
o Identify and provide valuable data inputs for modelers in their toxicokinetic and exposure models.
o Use modeling tools to understand the exposures of humans to chemicals related to biomarkers of exposure.
o Form a collaborative partnership with CDC to develop analytical methods for chemicals used as biomarkers of exposure in humans.
o Develop statistical methods and models to assess human exposures to chemicals of concern.
Description:
Direct assessment of cumulative risks is a difficult task due to combinations of multiple chemicals, exposure pathways, and concentration profiles using suites of environmental measurements. We are investigating the use of endogenous compounds commonly present in biological media and their changes in response to environmental stressors to indicate preclinical effects of complex exposures on metabolite expression.