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A PHYSIOLOGICALLY BASED COMPUTATIONAL MODEL OF THE BPG AXIS IN FATHEAD MINNOWS: PREDICTING EFFECTS OF ENDOCRINE DISRUPTING CHEMICAL EXPOSURE ON REPRODUCTIVE ENDPOINTS
Citation:
WATANABE, K., Z. LI, K. KROLL, N. REYERO, N. SZABO, M. SEPULVEDA, E. ORLANDO, D. L. VILLENEUVE, M. BREEN, G. T. ANKLEY, AND N. DENSLOW. A PHYSIOLOGICALLY BASED COMPUTATIONAL MODEL OF THE BPG AXIS IN FATHEAD MINNOWS: PREDICTING EFFECTS OF ENDOCRINE DISRUPTING CHEMICAL EXPOSURE ON REPRODUCTIVE ENDPOINTS. Presented at International Science Forum on Computational Toxicology, Research Triangle Park, NC, May 21 - 23, 2007.
Description:
This presentation describes development and application of a physiologically-based computational model that simulates the brain-pituitary-gonadal (BPG) axis and other endpoints important in reproduction such as concentrations of sex steroid hormones, 17-estradiol, testosterone, and 11-ketotestosterone; and vitellogenin, a precursor to the major egg yolk protein.