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COMPARATIVE DISTRIBUTION OF PERFLUOROOCTANOIC ACID IN MALE, FEMALE AND PREGNANT MICE FOLLOWING TREATMENT WITH 8-2 FLUOROTELOMER ALCOHOL (FTOH)
Citation:
HENDERSON, W. M. AND M. A. SMITH. COMPARATIVE DISTRIBUTION OF PERFLUOROOCTANOIC ACID IN MALE, FEMALE AND PREGNANT MICE FOLLOWING TREATMENT WITH 8-2 FLUOROTELOMER ALCOHOL (FTOH). Presented at 46th Annual Meeting of the Society of Toxicology, Charlotte, NC, March 25 - 29, 2007.
Impact/Purpose:
The general goals of this research are to meet OPPT's need for data and information regarding the stability of TBPPs in soils. We plan to address these needs with a series of lab experiments in which FBPs are exposed to selected natural and amended soils. We anticipate that, as we learn about the general behavior of FBPs in soils, we will develop a protocol for testing FBPs in soils that has procedures similar to the guidelines described in OECD 307.
Description:
The global occurrence of perfluorooctanoic acid (PFOA) in environmental and mammalian matrices has spurred regulatory interest in potential sources of this stable compound. 8-2 fluorotelomer alcohol, a primary compound used in polymer synthesis, is found ubiquitously in the environment and can undergo biotic and abiotic transformation to PFOA. An appropriate animal model is needed to fully elucidate the mechanisms of 8-2 FTOH metabolism and distribution of metabolites in mammals. The objective of this study was to compare the metabolism of 8-2 FTOH in male, female and pregnant mice.