EPA Science Inventory

MECHANISTIC COMPUTATIONAL MODEL OF STEROIDOGENESIS IN H295R CELLS: PREDICTING BIOCHEMICAL RESPONSE TO ENDOCRINE ACTIVE CHEMICALS (EAC).

Citation:

BREEN, M., M. BREEN, N. TERASAKI, M. YAMAZAKI, D. L. VILLENEUVE, AND R. CONOLLY. MECHANISTIC COMPUTATIONAL MODEL OF STEROIDOGENESIS IN H295R CELLS: PREDICTING BIOCHEMICAL RESPONSE TO ENDOCRINE ACTIVE CHEMICALS (EAC). Presented at International Science Forum on Computational Toxicology, RTP, NC, May 21 - 23, 2007.

Description:

Steroids, which have an important role in a wide range of physiological processes, are synthesized primarily in the gonads and adrenal glands through a series of enzyme-mediated reactions.

Purpose/Objective:

Steroids, which have an important role in a wide range of physiological processes, are synthesized primarily in the gonads and adrenal glands through a series of enzyme-mediated reactions.

URLs/Downloads:

Mechanistic Computational Model of Steroidogenesis in H295R Cells: Predicting Biochemical Response to Endocrine Active Chemicals.   (PDF,NA pp, 12 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (PRESENTATION/ABSTRACT)
Start Date: 05/22/2007
Completion Date: 05/22/2007
Record Last Revised: 12/03/2008
Record Created: 03/02/2007
Record Released: 03/02/2007
OMB Category: Other
Record ID: 165285

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR COMPUTATIONAL TOXICOLOGY

IMMEDIATE OFFICE