Science Inventory

Aeromonas Caviae Strain Induces Th1 Cytokine Response in Mouse Intestinal Tract

Citation:

HAYES, S. L., D. J. LYE, C. A. MCKINSTRY, AND S. J. VESPER. Aeromonas Caviae Strain Induces Th1 Cytokine Response in Mouse Intestinal Tract. CANADIAN JOURNAL OF MICROBIOLOGY. NRC Research Press, Ottawa, Canada, 56(1):27-31, (2010).

Impact/Purpose:

Journal Article

Description:

Aeromonas caviae has been associated with human gastrointestinal disease. Strains of this species typically lack virulence factors (VFs) such as enterotoxins and hemolysins that are produced by other human pathogens of the Aeromonas genus. Microarray profiling of murine small intestinal extracts, 24 hours after oral infection with an A. caviae strain, provides evidence of a Th1 type immune response. A large number of gamma-interferon (γ-IFN) induced genes are up-regulated as well as several tumor necrosis factor-alpha (TNF-α) transcripts. A. caviae has always been considered an opportunistic pathogen because it lacks obvious virulence factors. This current effort suggests A. caviae colonizes murine intestinal tract and causes what has been described by others as a dysregulatory cytokine response leading to an irritable bowel-like syndrome. This response would explain why a number of diarrheal waterborne outbreaks have been attributed to A. caviae even though it lacks obvious enteropathogenic properties.

URLs/Downloads:

Canadian Journal of Microbiology   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 01/25/2010
Record Last Revised: 02/02/2010
OMB Category: Other
Record ID: 164207

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL RISK MANAGEMENT RESEARCH LABORATORY

WATER SUPPLY AND WATER RESOURCES DIVISION

MICROBIAL CONTAMINANTS CONTROL BRANCH