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A REVIEW OF THE RODENT CARCINOGENICTY AND MUTAGENICITY OF AMBIENT AIR
Citation:
CLAXTON, L. D. AND G. M. WOODALL. A REVIEW OF THE RODENT CARCINOGENICTY AND MUTAGENICITY OF AMBIENT AIR. MUTATION RESEARCH - REVIEWS. Elsevier Science Ltd, New York, NY, 636(1-3):36-94, (2007).
Impact/Purpose:
The editors of Mutation Research decided to create a second special review volume on what is known about genotoxic (mutagenic and carcinogenic) pollutants in the environment. As part of the volume, the authors were asked to review the carcinogenicity and mutagenicity of urban air pollution.
Description:
This is a review of the information known about the carcinogenicity and mutagenicity of urban outdoor air including volatile pollutants and particulate organic material. The editors of Mutation Research decided to create a second special review volume on what is known about genotoxic (mutagenic and carcinogenic) pollutants in the environment. As part of the volume, the authors were asked to review the carcinogenicity and mutagenicity of urban air pollution. A need exists to bring together a listing and analysis of studies that have examined the genotoxicity of urban air samples in order to aid on-going research and evaluation/risk efforts. There is an existing need to bring together information that compares the levels of airborne genotoxicants due to differences in sources, atmospheric transformation processes, meteorology, and methods used to evaluate such levels. There is also a need to evaluate the utility of differing research approaches for understanding the sources, levels, and exposures to airborne toxicants. By understanding what types and levels of airborne genotoxicants to which humans and the environment are exposed, those involved in protecting public health can apply more informed and sophisticated methods to evaluating the potential effects of airborne mutagens and carcinogens. Such analyses will help researchers and others to identify potential sources and processes that affect the levels of genotoxicants and will help those involved in research, regulation, and management processes be informed as to current methods for identifying, quantifying, and evaluating airborne toxicants.
