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DEVELOPMENT, VALIDATION AND FIELD USE OF NOVEL METHOD FOR EXTRACTING AND ANALYZING ORGANOPHOSPHATE (OP) AND PYRETHROID PESTICIDE METABOLITES AND CREATININE FROM COMMERCIALLY AVAILABLE DISPOSABLE DIAPERS
NISHIOKA, M., K. ANDREWS, M. MCCAULEY, R. C. FORTMANN, AND J. WILKINS. DEVELOPMENT, VALIDATION AND FIELD USE OF NOVEL METHOD FOR EXTRACTING AND ANALYZING ORGANOPHOSPHATE (OP) AND PYRETHROID PESTICIDE METABOLITES AND CREATININE FROM COMMERCIALLY AVAILABLE DISPOSABLE DIAPERS. Presented at ISEA/ISEE 2006 , Paris, FRANCE, September 02 - 06, 2006.
The overall goal of this research program is to identify those chemicals, pathways, and activities that represent the highest potential exposures to children and to determine the factors that influence these exposures. The following objectives will address this goal:
Revise and refine the existing research plan for children's exposure measurements research.
Collect measurement data on children's exposures.
Provide analytical support to children's pesticide exposure research.
Develop analytical methods for pesticides in duplicate diet food samples.
Develop and apply analytical methods for other chemicals including but not limited to brominated diphenyl ethers, phthalates, perfluorinated chemicals.
Evaluate the impact of chiral chemistry on the risk to children and exposure assessment.
Provide support to the National Children's Study.
Perform data analyses to fill critical data gaps.
Conduct analyses of dietary samples and refine the dietary model for the dietary exposure algorithm.
The ability to efficiently extract urine from disposable diapers ensures an easy to use urine collection protocol and ready compliance for caregivers of very young children. The use of disposable diapers is also desirable because of their high capacity- urine is retained effectively overnight (12-14 hr for young children), thus providing integration of excretion over 50% of a day.