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CONTINUOUS FLOW MICROWAVE REACTORS FOR ORGANIC SYNTHESIS: HYDRODECHLORINATION, HETROCYCLIZATION, ISOMERIZATION
Citation:
SAHLE-DEMESSIE, E. AND V. GOPAL DEVULAPELLI. CONTINUOUS FLOW MICROWAVE REACTORS FOR ORGANIC SYNTHESIS: HYDRODECHLORINATION, HETROCYCLIZATION, ISOMERIZATION. Presented at International Microwave Power Institute's 40th Annual Symposium, Boston, MA, August 09 - 11, 2006.
Impact/Purpose:
To inform the public.
Description:
Microwave heating has been sought as a convenient way of enhancing chemical processes. The advantages of microwave heating, such as selective direct heating of materials of a catalytic site, minimized fouling on hot surfaces, process simplicity, rapid startup, as well as the possibility of solventless (or "dry") reactions and enhanced chemistry, demonstrate that many processes could be applied in the chemical and pharmaceutical industry. We are testing the viability of microwave technology for assisting organic synthesis and assessing the scalability by developing products from micrograms to kilograms. The feasibility of conducting continuous-flow reactors was determined to better understand scale-up possibilities. Flow-through microwave reactor is used that is capable of scaling up single-mode yield. Problems connected with temperature control, energy consumption and optimizing the conditions for microwave assisted synthesis are studied. Homogeneous multiphase reactions including hydrodechlorination of chloroflorocarbons and chlorobenzenes, synthesis of heterocyclic N-oxides, and isomerization of m-xylene were used as model reactions.