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A Conceptual Systems Model to Facilitate Hypothesis-driven Ecotoxicogenomics Research on the Teleost Brain-pituitary-gonadal Axis
Citation:
VILLENEUVE, D. L., P. LARKIN, I. KNOEBL, A. L. MIRACLE, M. D. KAHL, K. M. JENSEN, E. A. MAKYNEN, E. J. DURHAN, B. CARTER, N. D. DENSLOW, AND G. T. ANKLEY. A Conceptual Systems Model to Facilitate Hypothesis-driven Ecotoxicogenomics Research on the Teleost Brain-pituitary-gonadal Axis. ENVIRONMENTAL SCIENCE AND TECHNOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 41(1):321-330, (2007).
Impact/Purpose:
To present an overview of a novel open-source conceptuial model of molecular and biochemical pathways involved in the regulation of fish reproduction
Description:
This provides an overview of a novel open-source conceptuial model of molecular and biochemical pathways involved in the regulation of fish reproduction. Further, it provides concrete examples of how such models can be used to design and conduct hypothesis-driven "omics" experiments and how they can be used to help draw meaning from complex datasets of inter-related endpoints.