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MOLECULAR MODELS OF PARATHYROID METABOLISM BY CARBOXYLESTERASES: DIFFERENTIAL EFFECTS DUE TO STEREOCHEMISTRY.
Citation:
PASQUINELLI, M., R. TORNERO-VELEZ, AND J. R. RABINOWITZ. MOLECULAR MODELS OF PARATHYROID METABOLISM BY CARBOXYLESTERASES: DIFFERENTIAL EFFECTS DUE TO STEREOCHEMISTRY. Presented at BOARD OF SCIENTIFIC COUNSELORS (BOSC), RTP, NC, June 19 - 20, 2006.
Impact/Purpose:
PARATHYOIDS ARE A CHEMICAL CLASS OF WIDELY USED INSECTICIDES, & AT LEAST 16 CHEMICALS IN THIS CLASS ARE REGISTERED FOR USE IN THE US. IN ORDER TO EXTRAPOLATE THE KNOWLEDGE FROM RODENTS TO HUMANS, PHYSIOLOGICALLY-BASED PHARMACOKINETIC (pbpk) MODELS ARE CURRENTLY BEING DEVELOPED.
Description:
PARATHYROIDS ARE A CHEMICAL CLASS OF WIDELY USED INSECTICIDES, & AT LEAST 16 CHEMICALS IN THIS CLASS ARE REGISTERED FOR USE IN THE US. IN ORDER TO EXTRAPOLATE THE KNOWLEDGE FROM RODENTS TO HUMANS, PHYSIOLOGICALLY-BASED PHARMACOKINETIC (pbpk) MODELS ARE CURRENTLY BEING DEVELOPED.