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AN ENZYME LINKED IMMUNOSORBENT ASSAY (ELISA) METHOD FOR MONITORING 2,4 DICHLOROPHENOXYACETIC ACID (2,4-D) EXPOSURES
VAN EMON, J. M., J. C. CHUANG, J. DURNFORD, AND K. W. THOMAS. AN ENZYME LINKED IMMUNOSORBENT ASSAY (ELISA) METHOD FOR MONITORING 2,4 DICHLOROPHENOXYACETIC ACID (2,4-D) EXPOSURES. Presented at American Chemical Society National Meeting, San Francisco, CA, September 10 - 14, 2006.
The overall goal of this research program is to identify those chemicals, pathways, and activities that represent the highest potential exposures to children and to determine the factors that influence these exposures. The following objectives will address this goal:
Revise and refine the existing research plan for children's exposure measurements research.
Collect measurement data on children's exposures.
Provide analytical support to children's pesticide exposure research.
Develop analytical methods for pesticides in duplicate diet food samples.
Develop and apply analytical methods for other chemicals including but not limited to brominated diphenyl ethers, phthalates, perfluorinated chemicals.
Evaluate the impact of chiral chemistry on the risk to children and exposure assessment.
Provide support to the National Children's Study.
Perform data analyses to fill critical data gaps.
Conduct analyses of dietary samples and refine the dietary model for the dietary exposure algorithm.
Abstract describes a streamlined ELISA method developed to quantitatively measure 2,4-D in human urine samples. Method development steps and comparison with gas chromatography/mass spectrometry are presented. Results indicated that the ELISA method could be used as a high throughput, quantitative monitoring tool for identifying individuals with exposure to 2,4-D above typical background levels.