Science Inventory

DIAGNOSTIC CRITERIA FOR PROLIFERATIVE THYROID LESIONS IN BONY FISHES II

Citation:

FOURNIE, J. W., M. J. WOLFE, J. C. WOLF, R. D. JOHNSON, L. A. COURTNEY, AND W. E. HAWKINS. DIAGNOSTIC CRITERIA FOR PROLIFERATIVE THYROID LESIONS IN BONY FISHES II. Presented at 5th International Symposium on Aquatic Animal Health, San Francisco, CA, September 02 - 06, 2006.

Impact/Purpose:

Conference abstract

Description:

Thyroid proliferative lesions are rather common in bony fishes but diagnostic terminology and criteria for these lesions are inconsistent in the literature. The diagnosis of proliferative thyroid lesions is especially challenging in fish due to the fact that the thyroid is not a discrete organ in most species.To simplify lesion interpretation and standardize the nomenclature, we propose specific criteria for distinguishing hyperplastic versus neoplastic changes, benign versus malignant neoplasms, and metatastic tumors versus ectopic thyroid tissue. Development of these criteria was based on the examination of a large series of thyroid masses from Japanese medaka (Oryzias latipes), and other small fish species, and a reexamination of the 97 cases of proliferative thyroid lesions from the Registry of Tumors in Lower Animals collection. Specific diagnostic features are described for the primary categories of follicular cell hyperplasia, adenoma, and carcinoma, and for several proposed sub-categories.These criteria should assist fish pathologists in communicating and reporting findings regarding thyroid proliferative lesions.

Record Details:

Record Type: DOCUMENT (PRESENTATION/ABSTRACT)
Product Published Date: 09/02/2006
Record Last Revised: 07/27/2012
OMB Category: Other
Record ID: 154874

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

GULF ECOLOGY DIVISION

BIOLOGICAL EFFECTS AND POPULATION RESPONSE BRANCH