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AN ALTERNATIVE METHOD FOR ESTABLISHING TEFS FOR DIOXIN-LIKE COMPOUNDS. PART 3. DEVEOPMENT OF WEIGHTED DISTRIBUTIONS OF REPS FOR PCB 126 AND 2,3,4,7,8-PECDF
Citation:
STASKAL, D., K. M. UNICE, N. J. WALKER, M. J. DEVITO, L. S. BIRNBAUM, P. K. SCOTT, M. A. HARRIS, W. H. FARLAND, B. L. FINLEY, AND L. C. HAWS. AN ALTERNATIVE METHOD FOR ESTABLISHING TEFS FOR DIOXIN-LIKE COMPOUNDS. PART 3. DEVEOPMENT OF WEIGHTED DISTRIBUTIONS OF REPS FOR PCB 126 AND 2,3,4,7,8-PECDF. Presented at 26th International Symposium on Halogenated Persistent Organic Pollutants, Oslo, NORWAY, August 21 - 25, 2006.
Description:
Currently, regulatory agencies utilize the toxic equivalency factor (TEF) approach to evaluate potential health risks associated with exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (PCBs). The current TEF methodology has been identified as "interim," and, as such, is subject to periodic review as new information becomes available. When the current World Health Organization (WHO) TEFs were established, the expert panel relied upon a series of decision criteria to assess the relative importance of the underlying relative estimates of potency (REP) in assigning a consensus-based TEF for each congener. However, because this was a qualitative process, it is not possible to characterize the variability and uncertainty inherent in the risk estimates that are based on the WHO TEFs.