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A FACILE ONE-POT SYNTHESIS OF β-KETO SULFONES FROM KETONES UNDER SOLVENT-FREE CONDITIONS
Citation:
KUMAR, D., S. SUNDAREE, V. S. RAO, AND R. S. VARMA. A FACILE ONE-POT SYNTHESIS OF β-KETO SULFONES FROM KETONES UNDER SOLVENT-FREE CONDITIONS. B. Ganem (ed.), TETRAHEDRON LETTERS. Elsevier Science Ltd, New York, NY, 47(25):4197-4199, (2006).
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Description:
An easy solvent-free method is described for the conversion of ketones into β-keto sulfones in high yields that involves in situ generation of α-tosyloxyketones followed by nucleophilic substitution with sodium arene sulfinate in presence of tetra-butylammonium bromide at room temperature. The salient features of this one-pot protocol are short reaction times, cleaner reaction profiles, and simple work-up that precludes the use of toxic solvents.
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A FACILE ONE-POT SYNTHESIS OF β-KETO SULFONES FROM KETONES UNDER SOLVENT-FREE CONDITIONS
Record Details:
Record Type:DOCUMENT( JOURNAL/ PEER REVIEWED JOURNAL)
Product Published Date:06/19/2006
Record Last Revised:07/16/2008
OMB Category:Other
Record ID:
153894