Science Inventory

REVISITING CLASSICAL NUCLEOPHILIC SUBSTITUTIONS IN AQUEOUS MEDIUM: MICROWAVE-ASSISTED SYNTHESIS OF ALKYL AZIDES

Citation:

JU, Y., D. KUMAR, AND R. S. VARMA. REVISITING CLASSICAL NUCLEOPHILIC SUBSTITUTIONS IN AQUEOUS MEDIUM: MICROWAVE-ASSISTED SYNTHESIS OF ALKYL AZIDES. Presented at 231st ACS National Meeting, Atlanta, GA, March 26 - 30, 2006.

Impact/Purpose:

To inform the public

Description:

An efficient and clean synthesis of alkyl azides using microwave (MW) radiation is described in aqueous medium by reacting alkyl halides or tosylates with alkali azides. This general and expeditious MW-enhanced approach to nucleophilic substitution reactions is applicable to the formation alkyl thiocyanides with added advantage that various functional groups such as ester, carboxylic acid, carbonyl and hydroxyl etc. are tolerated under mild reaction conditions that does not require the use of a phase transfer reagent. Our exploration of this catalyst-free strategy to accomplish MW-assisted one-pot 1,3-dipolar cycloaddition reaction of alkynes with in situ generated alkyl azides will be discussed.

Record Details:

Record Type: DOCUMENT (PRESENTATION/ABSTRACT)
Product Published Date: 03/27/2006
Record Last Revised: 04/24/2008
OMB Category: Other
Record ID: 153887

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL RISK MANAGEMENT RESEARCH LABORATORY

SUSTAINABLE TECHNOLOGY DIVISION

CLEAN PROCESSES BRANCH