EPA Science Inventory

EXPOSURES AND INTERNAL DOSES OF TRIHALOMETHANES IN HUMANS: MULTI-ROUTE CONTRIBUTIONS FROM DRINKING WATER (FINAL)

Citation:

U.S. EPA. EXPOSURES AND INTERNAL DOSES OF TRIHALOMETHANES IN HUMANS: MULTI-ROUTE CONTRIBUTIONS FROM DRINKING WATER (FINAL). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-06/087, 2006.

Description:

The National Center for Environmental Assessment (NCEA) has released a final report that presents and applies a method to estimate distributions of internal concentrations of trihalomethanes (THMs) in humans resulting from a residential drinking water exposure. The report presents simulations of oral, dermal and inhalation exposures and demonstrates the feasibility of linking the US EPA’s information Collection Rule database with other databases on external exposure factors and physiologically based pharmacokinetic modeling to refine population-based estimates of exposure.

Purpose/Objective:

Review Draft - by 2010, develop scientifically sound data and approaches to assess and manage risks to human health posed by exposure to specific regulated waterborne pathogens and chemicals, including those addressed by the Arsenic, M/DBP and Six-Year Review Rules.

URLs/Downloads:

THE FEASIBILITY OF PERFORMING CUMULATIVE RISK ASSESSMENTS FOR MIXTURES OF DISINFECTION BY-PRODUCTS IN DRINKING WATER

DEVELOPMENT OF A METHOD TO QUANTIFY THE IMPACT OF HUMAN BIOCHEMICAL INDIVIDUALITY IN THE PRODUCTION OF RISK-RELEVANT PHARMACOKINETIC OUTCOMES IN ADULTS AND CHILDREN

Exposures and Internal Doses of Trihalomethanes in Humans: Multi-Route Contributions from Drinking Water (Final)   (PDF,251 pp, 3323 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (PUBLISHED REPORT/REPORT)
Start Date: 11/02/2006
Completion Date: 11/02/2006
Record Last Revised: 06/24/2009
Record Created: 05/03/2006
Record Released: 05/03/2006
Record ID: 153303

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT

CINCINNATI OH

RISK ASSESSMENT SUPPORT