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ENANTIOMER-SPECIFIC FATE AND EFFECTS OF MODERN CHIRAL PESTICIDES
GARRISON, A. W. ENANTIOMER-SPECIFIC FATE AND EFFECTS OF MODERN CHIRAL PESTICIDES. Presented at Workshop on Chiral Xeniobiotics, Birmingham, UK, March 28, 2006.
To determine the environmental occurrences, fate, and effects of the enantiomers of selected chiral pesticides and other chiral pollutants.
This slide presentation presents enantiomer-specific fate and effects of modern chiral pesticides. The research areas presented were analytical separation of enantiomers; environmental occurrence of enantiomers; transformation rates and enantioselectivity; bioaccumulation; and enantioselectivity effects. Conclusions of the presentation were many modern pesticides are chiral; capillary electrophoresis is useful for laboratory studies of pesticide transformation; microbial transformation is usually observed to be enantioselective, but it is not possible at this time to predict the direction or extent of selectivity in a different environment; and enantiomers usually differ in their effects, including toxicity and ED activity, but little definitive work has been done with pesticides; metabonomics, proteomics and other modern molecular biochemistry techniques are applicable to investigate toxicity mechanisms; accurate risk assessment requires investigation of the fate and effects of each enantiomer of a chiral pesticide; and the ultimate goal of this research is to show whether the manufacture and use of single-enantiomer pesticides is of benefit to the environment.
Record Details:Record Type: DOCUMENT (PRESENTATION/ABSTRACT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL EXPOSURE RESEARCH LABORATORY
ECOSYSTEMS RESEARCH DIVISION
PROCESSES & MODELING BRANCH