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REGIONAL DEPOSITION DOSE OF INHALED NANO-SIZE PARTICLES IN HUMAN LUNGS DURING CONTROLLED NORMAL BREATHING
Citation:
KIM, C. S., P. JAQUES, AND S. HU. REGIONAL DEPOSITION DOSE OF INHALED NANO-SIZE PARTICLES IN HUMAN LUNGS DURING CONTROLLED NORMAL BREATHING. Presented at International Aerosol Conference, St. Paul, MN, September 10 - 15, 2006.
Description:
INTRODUCTION
One of the key factors for affecting respiratory
deposition of particles is the breathing pattern of
individual subjects. Although idealized breathing
patterns (square or sine wave form) are frequently used
for studying lung deposition, respiratory flow patterns
are usually skewed and the inspiratory to expiratory
ratios vary widely, particularly among patients with
lung disease. Recent studies (Roth et al., 2003)
suggested that a sinusoidal wave flow pattern is more
efficient to deliver nebulised aerosols than square wave
form. However, a systematic study is needed to fully
understand effects of flow patterns on modulating
particle deposition in the lung. In the present study, we
investigated variations of both total and regional
deposition with different flow wave patterns for a wide
range of particle diameter (0.01-5µm).