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BIOMONIITORING RESEARCH WITHIN THE U.S. EPA'S OFFICE OF RESEARCH AND DEVELOPMENT
Citation:
SHELDON, L. S. BIOMONIITORING RESEARCH WITHIN THE U.S. EPA'S OFFICE OF RESEARCH AND DEVELOPMENT. Presented at 2006 ILSI Annual Meeting , San Juan, PUERTO RICO, January 13 - 19, 2006.
Impact/Purpose:
1) Identify potential pathways of exposure for chemicals of interest based regulatory assumptions, product use labels and existing field study data.
2)Develop chemical or class specific PBPK/PD models suitable for biomarker analysis
3)Generate PBPK/PD model output to include simulation-based distributions of projected biomarkers from exposure time-histories.
4)Test biomarker data from human exposure field studies against the in silicoderived prior distributions of exposure to produce ?posterior? distributions.
5)Derive PK and PD dose metrics and calculate cumulative risks.
Description:
Current ORD exposure research is directed toward developing the processes, tools, and information to put biomonitoring data into perspective for the risk assessment process, to define the appropriate uses of specific biomarkers, and to integrate biomarker measurements with exposure and internal dose