EPA Science Inventory

EFFECTS OF FOUR TRIHALOMETHANES ON DNA STRAND BREAKS, RENAL HYALINE DROPLET FORMATION AND SERUM TESTOSTERONE IN MALE F-344 RATS

Contact
ANTHONY B DEANGELO
phone: 9195412568
fax: 919-685-3279
email: deangelo.anthony@epa.gov


Contact
CARL L POTTER
phone: 5135697231
email: Not Provided


Contact
LINA W CHANG
phone: 5135697442
fax: 513/569-7609
email: Chang.Lina@epa.gov


Contact
FRANCIS B DANIEL
phone: 5135697401
email: Daniel.Bernie@epa.gov


Citation:

Potter, C., L. Chang, A. Deangelo, AND F. Daniel. EFFECTS OF FOUR TRIHALOMETHANES ON DNA STRAND BREAKS, RENAL HYALINE DROPLET FORMATION AND SERUM TESTOSTERONE IN MALE F-344 RATS. Cancer Letters 106(2):235-242, (1996).

Description:

All four possible trihalomethanes (THMs) containing bromine and chlorine, as well as perchloroethylene (PCE), were evaluated for their ability to produce DNA strand breaks, a2u-globulin rich renal deposits, and testosterone changes in male F-344 rats. Rats received daily equimolar doses (0.75 or 1.5 mmol/kg) of THMs or PCE (1000 mg/kg) in 4% Emulphor vehicle by oral gavage for 7 days. No significant DNA strand breaks were produced by any THM or PCE treatment, PCE treatment produced increased hyaline droplet formation in renal tubules. However, all THM treatment reduced or eliminated the appearance of renal hyaline droplets. All four THM treatments also produced a decrease in serum testosterone concentrations on day 7, which might account for decreased hyaline droplet formation. No significant increase in cell proliferation, measured by [3H]thymidine incorporation in vivo, appeared in this 1-week study.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 09/10/1996
Completion Date: 09/10/1996
Record Last Revised: 12/22/2005
Record Created: 05/09/2000
Record Released: 05/09/2000
Record ID: 14464

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT