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Evaluation of the Methoxytriazine Herbicide Prometon Using a Short-term Fathead Minnow Reproduction Test and a Suite of in vitro Bioassays
Citation:
VILLENEUVE, D. L., M. B. MURPHY, M. D. KAHL, K. M. JENSEN, B. C. BUTTERWORTH, E. A. MAKYNEN, E. J. DURHAN, A. L. LINNUM, R. L. LEINO, L. R. CURTIS, J. P. GIESY, AND G. T. ANKLEY. Evaluation of the Methoxytriazine Herbicide Prometon Using a Short-term Fathead Minnow Reproduction Test and a Suite of in vitro Bioassays. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 25(8):2143-2153, (2006).
Impact/Purpose:
to assess whether methoxytriazine herbicides act as endocrine disruptors
Description:
This study used an array of in vitro bioassays to assess whether prometon, atraton, terbumeton, or secbumeton might act as potent (ant)agonists of the aryl hydrocarbon, estrogen, androgen, or glucocorticoid receptors and whether they might act as aromatase inhibitors or inducers in vitro.