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CHEMICALLY-INDUCED SKIN IRRITATION: COMPUTATIONAL MODEL OF INTRACELLULAR SIGNALING PATHWAYS THAT MEDIATE INFLAMMATORY RESPONSE

Contact

email: CCTE@epa.gov

Citation:

BREEN, M., Y. ZENG, Q. ZHANG, J. MCDOUGAL, P. SHI, AND R. CONOLLY. CHEMICALLY-INDUCED SKIN IRRITATION: COMPUTATIONAL MODEL OF INTRACELLULAR SIGNALING PATHWAYS THAT MEDIATE INFLAMMATORY RESPONSE. Presented at 2006 Annual Society of Toxicology, San Diego, CA, March 05 - 09, 2006.

Impact/Purpose:

Dermal exposure to chemical irritants induces a local inflammatory response through cytokinemediated stimulation of signaling pathways. We are developing a computational model of the intracellular signaling pathways that mediate the acute inflammatory response to describe the dose-response for skin irritants.

Description:

Computer simulations were performed to examine dose and time responses, and compared with the limited amount of available, relevant experimental data.

URLs/Downloads:

BREEN SOT 2006 ABSTRACT V2.PDF  (PDF, NA pp,  62  KB,  about PDF)

Record Details:

Record Type:DOCUMENT( PRESENTATION/ ABSTRACT)
Product Published Date:03/06/2006
Record Last Revised:12/24/2008
OMB Category:Other
Record ID: 141403