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IRIS Toxicological Review of Butyl Benzyl Phthalate (BBP) (Preliminary Assessment Materials, 2014)

Contact

phone: (202) 566-1676
fax: (202) 566-1749
email: hotline.iris@epa.gov

Citation:

U.S. EPA. IRIS Toxicological Review of Butyl Benzyl Phthalate (BBP) (Preliminary Assessment Materials, 2014). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/008, 2014.

Impact/Purpose:

The U.S. EPA is conducting a reassessment of the scientific basis supporting the human health risk assessment of butyl benzyl phthalate (BBP) that will appear on the Agency's online database, the Integrated Risk Information System (IRIS). IRIS is an EPA database containing Agency consensus scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment process, i.e., hazard identification and dose-response evaluation. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risks associated with environmental contaminants.

Description:

In September 2014, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for BBP to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in comments on the following:

  • Draft literature search strategies
  • The approach for identifying studies
  • The screening process for selecting pertinent studies
  • The resulting list of pertinent studies
  • Preliminary evidence tables
  • The process for selecting studies to include in evidence tables
  • The quality of the studies in the evidence tables
The literature search strategy, which describes the processes for identifying scientific literature, contains the studies that EPA considered and selected to include in the evidence tables. The preliminary evidence tables and exposure-response arrays present the key study data in a standardized format. The evidence tables summarize the available critical scientific literature. The exposure-response figures provide a graphical representation of the responses at different levels of exposure for each study in the evidence table.

URLs/Downloads:

Scoping Information, Preliminary Literature Search, Associated Strategy and Evidence Tables for BBP  (PDF, 282 pp,  4780  KB,  about PDF)

BBP Errata Sheet  (PDF, 1 pp,  367  KB,  about PDF)

HERO Primary literature search references sorted by author (BBP) (dynamic literature link - generated by HERO, leaving the IRIS website)

HERO Literature selection process for the BBP primary literature (dynamic literature link - generated by HERO, leaving the IRIS website)

HERO Mechanistic table (BBP) (dynamic literature link - generated by HERO, leaving the IRIS website)

HERO Targeted literature search for epidemiological references sorted by author (phthalate) (dynamic literature link - generated by HERO, leaving the IRIS website)

HERO Literature selection process for the BBP targeted epidemiological literature (dynamic literature link - generated by HERO, leaving the IRIS website)

IRIS Public Science Meeting (Feb 2015)

Record Details:

Record Type:DOCUMENT( IRIS ASSESSMENT)
Product Published Date:09/29/2014
Record Last Revised:03/25/2019
OMB Category:Other
Record ID: 138285