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COMPARATIVE MUTAGENICITY OF HALOMETHANES AND HALONITROMETHANES IN SALMONELLA TA100: STRUCTURE-ACTIVITY ANALYSIS AND MUTATION SPECTRA. (ERD)
Citation:
KUNDU, B., S. D. RICHARDSON, C. GRANVILLE, D. T. SHAUGHNESSY, N. M. HANLEY, P. SWARTZ, A. M. RICHARD, AND D. M. DEMARINI. COMPARATIVE MUTAGENICITY OF HALOMETHANES AND HALONITROMETHANES IN SALMONELLA TA100: STRUCTURE-ACTIVITY ANALYSIS AND MUTATION SPECTRA. (ERD). MUTATION RESEARCH. Elsevier Science Ltd, New York, NY, 554(1-2):335-350, (2004).
Impact/Purpose:
(1) Use toxicity-based approach to identify DBPs that show the greatest toxic response. (2) Comprehensively identify DBPs formed by different disinfectant regimes for the 'Four Lab Study'. (3) Determine the mechanisms of formation for potentially hazardous bromonitromethane DBPs.
Description:
Halonitromethanes (HNMs) are a recently identified class of disinfection by-products (DPBs) in drinking water that are mutagenic in Salmonella and potent inducers of DNA strand breaks in mammalian cells. Here we compared the mutagenic potencies of the HNMs to those of their halomethane (HM) homologues by testing all nine HNMs and seven of the nine HMs (minus bromomethane and chloromethane) under the same conditions (the pre-incubation assay) in Salmonella TA100 +/- S9. We also determined the mutation spectra for several DBPs. In the presence of S9, all nine HNMs, but only three HMs, dibromomethane (DBM), dichloromethane (DCM), and bromochloromethane (BCM), were mutagenic. Only two DBPs of each class were mutagenic in the absence of S9.