EPA Science Inventory

MEETING AT BALTIMORE, MD: DISTRIBUTION OF CHIRAL PCBS IN SELECTED TISSUES IN THE LABORATORY RAT

Citation:

LEHMLER, H. J., I. KANIA-KORWEL, J. K. AVANTS, K. C. HORNBUCKLE, L. W. ROBERTSON, W. W. SULKOWSKI, AND A. W. GARRISON. MEETING AT BALTIMORE, MD: DISTRIBUTION OF CHIRAL PCBS IN SELECTED TISSUES IN THE LABORATORY RAT. Presented at Society of Environmental Toxicology and Chemistry Annual Meeting, Baltimore, MD, November 13 - 17, 2005.

Description:

In order to investigate the tissue distribution and enantiomeric fractions (EFs) of Polychlorinated Biphenyl (PCB) atropisomers, immature male Sprague-Dawley rats were administered environmentally relevant doses of (a) Aroclor 1254 or (b) an environmental mixture extracted from soil contaminated with Chlorofen, a Polish PCB mixture. The differences in the induction of PCB metabolizing enzymes may be responsible for the differences in the enantiomeric enrichment between both groups.

Purpose/Objective:

To determine the environmental occurrences, fate, and effects of the enantiomers of selected chiral pesticides and other chiral pollutants.

URLs/Downloads:

Record Details:

Record Type: DOCUMENT (PRESENTATION/ABSTRACT)
Start Date: 11/14/2005
Completion Date: 11/14/2005
Record Last Revised: 06/21/2006
Record Created: 06/20/2005
Record Released: 06/20/2005
Record ID: 134913

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL EXPOSURE RESEARCH LAB

ECOSYSTEMS RESEARCH DIVISION

PROCESSES & MODELING BRANCH