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MEETING AT BALTIMORE, MD: DISTRIBUTION OF CHIRAL PCBS IN SELECTED TISSUES IN THE LABORATORY RAT
LEHMLER, H. J., I. KANIA-KORWEL, J. K. AVANTS, K. C. HORNBUCKLE, L. W. ROBERTSON, W. W. SULKOWSKI, AND A. W. GARRISON. MEETING AT BALTIMORE, MD: DISTRIBUTION OF CHIRAL PCBS IN SELECTED TISSUES IN THE LABORATORY RAT. Presented at Society of Environmental Toxicology and Chemistry Annual Meeting, Baltimore, MD, November 13 - 17, 2005.
To determine the environmental occurrences, fate, and effects of the enantiomers of selected chiral pesticides and other chiral pollutants.
In order to investigate the tissue distribution and enantiomeric fractions (EFs) of Polychlorinated Biphenyl (PCB) atropisomers, immature male Sprague-Dawley rats were administered environmentally relevant doses of (a) Aroclor 1254 or (b) an environmental mixture extracted from soil contaminated with Chlorofen, a Polish PCB mixture. The differences in the induction of PCB metabolizing enzymes may be responsible for the differences in the enantiomeric enrichment between both groups.
Record Details:Record Type: DOCUMENT (PRESENTATION/ABSTRACT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL EXPOSURE RESEARCH LABORATORY
ECOSYSTEMS RESEARCH DIVISION
PROCESSES & MODELING BRANCH