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NEUROCHEMICAL EFFECTS OF CHRONIC DIETARY AND REPEATED HIGH-LEVEL ACUTE EXPOSURE TO CHLORPYRIFOS IN RATS.
Citation:
PADILLA, S. J., R. S. MARSHALL, D. L. HUNTER, S. OXENDINE, V. C. MOSER, S. B. SOUTHERLAND, AND R. B. MAILMAN. NEUROCHEMICAL EFFECTS OF CHRONIC DIETARY AND REPEATED HIGH-LEVEL ACUTE EXPOSURE TO CHLORPYRIFOS IN RATS. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 88(1):161-171, (2005).
Impact/Purpose:
To investigate the chronic neurotoxic effects of and organophosphorus, anticholinesterase pesticide: chlorpyrifos
Description:
Lots of information is available surrounding the acute toxicity of anticholinesterase pesticides, but these have been very few detailed studies on the chronic effects of these pesticides. Humans are exposed on a chronic basis and some humans believe that have been affected adversely. Our laboratory set out to investigate the chronic toxicity of one, commonly used organophosphorus, anticholinesterase pesticide, chlorpyrifos. Animals were given the pesticide for one year in their feed at both a high and low dose. It was found that brain chemistry was changed during dosing at the highest level, but 3 months after dosing had ceased, all the neurochemical endpoints had returned to normal