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ULTRAFINE CARBON PARTICLE (UFCP) INHALATION AFFECTS CARDIOVASCULAR PERFORMANCE IN HYPERTENSIVE RATS (SHR)
Citation:
HARDER, V., M. SCHLADWEILER, M. SEMMLER, S. TAKANAKA, E. KARG, P. REITMEIR, M. BADER, A. STAMPFL, U. P. KODAVANTI, AND H. SCHULZ. ULTRAFINE CARBON PARTICLE (UFCP) INHALATION AFFECTS CARDIOVASCULAR PERFORMANCE IN HYPERTENSIVE RATS (SHR). Presented at European Respiratory Society Annual Congress 2005, Copenhagen, DENMARK, September 17 - 21, 2005.
Description:
Inhaled UfCP affect cardiovascular performance in healthy rats (Harder et al. Inhal Toxicol 2005; 17:29-42) without apparent pulmonary damage. To assess whether geriatric cardiovascular compromised rats are more susceptible to UfCP effects, male adult (6months) and geriatric (13months) spontaneously Hypertensive rats (SHR) were exposed to air or UfCP (23nm; 5 106cm-3) for 24hrs. ECG and blood pressure were monitored telemetrically (n=28) over a 6day period covering baseline (day0), exposure (day1), and recovery period (days2-5). On day3, 48hrs after UfCP exposure heart rate was increased by 9.2 5.9% in adult (n.s.) and by 11.8 7.3% in geriatric SHR (p<0.05). Simultaneously, diastolic blood pressure was elevated by 6.1 4.4% in adult SHR (p<0.05) but not in geriatric rats. UfCP exposure in non-telemetry rats did not cause significant alterations in pulmonary toxicity as determined by analysis of biochemical and inflammatory markers in bronchoalveolar lavage fluid This suggests that cardiovascular effects in compromised rats are triggered by altered cardiac autonomic function with a lag of 2days post exposure, and are likely not influenced by UfCP-induced pulmonary impairments. (Does not reflect US EPA policy).