You are here:
EVALUATION OF NEW 2,2-DIMETHYL-5,5-DIPROPOXYBENZIDINE- AND 3,3-DIPROPOXYBENZIDINE-BASED DIRECT DYE ANALOGS FOR MUTAGENIC ACTIVITY BY USE OF THE SALMONELLA/MAMMALIAN MUTAGENICITY ASSAY
Citation:
Bae, J. S., H. S. Freeman, AND L D. Claxton. EVALUATION OF NEW 2,2-DIMETHYL-5,5-DIPROPOXYBENZIDINE- AND 3,3-DIPROPOXYBENZIDINE-BASED DIRECT DYE ANALOGS FOR MUTAGENIC ACTIVITY BY USE OF THE SALMONELLA/MAMMALIAN MUTAGENICITY ASSAY . MUTATION RESEARCH. Elsevier Science BV, Amsterdam, Netherlands, 603(2):173-185, (2006).
Impact/Purpose:
To evaluate new Direct Dye Analogs for mutagenicity using the Salmonella Mammalian Mutagenicity Assay
Description:
A series of new metallized and unmetallized direct dyes based on benzidine analogs, 2,2'dimethyl-5,5'-dipropoxybenzidine and 3,3'-dipropoxybenzidine, were evaluated for mutagenicity in Salmonella typhimurium strains TA98 and TA100. All of the dyes examined were judged non-mutagenic with and without metabolic activation while toxicity was seen in some dyes at high doses. The results of this study are consistent with the non-mutagenic properties of the diamines themselves and suggest that the present benzidine analogs are potential replacements for benzidine and its genotoxic congeners for the development of new azo dyes.