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APOPTOSIS OF CEREBELLAR GRANULE CELLS INDUCED BY ORGANOTIN COMPOUNDS FOUND IN DRINKING WATER: INVOLVEMENT OF MAP KINASES.
Citation:
Mundy, W R. AND T Freudenrich. APOPTOSIS OF CEREBELLAR GRANULE CELLS INDUCED BY ORGANOTIN COMPOUNDS FOUND IN DRINKING WATER: INVOLVEMENT OF MAP KINASES. NEUROTOXICOLOGY 27:71-81, (2006).
Impact/Purpose:
To determine the neurotoxicity of four mono- and dialkyl tins commonly found in drinking water
Description:
Mono- and dialkyl organotins have been found in drinking water in homes and businesses served by PVC pipes. Because the structurally related trialkyl organotins (eg. trimethyltin, tributyltin) are well known neurotoxicants, there is concern over the potential for the mono- and dialkyl tins to produce neurotoxicity. This research used an in vitro model to determine the neurotoxicity of four mono- and dialkyl tins commonly found in drinking water, and compared their potency to the known neurotoxicant trimethyltin. Of the organotins found in drinking water only one, dibutyltin, resulted in neuronal cell death. Dibutyltin was more potent than trimethyltin, and activated different toxicity pathways. Future in vivo studies should focus on the neurotoxic effects of dibutyltin