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THE ROLE OF MAMMALIAN DATA IN DETERMINING PHARMACEUTICAL RESPONSES IN AQUATIC ORGANISMS
Citation:
Huggett, D. B., J. C. Cook, W H. Benson, AND L. B. Kinter. THE ROLE OF MAMMALIAN DATA IN DETERMINING PHARMACEUTICAL RESPONSES IN AQUATIC ORGANISMS. Chapter 5, Robert T. Williams (ed.), Pharmaceuticals in the Environment. SETAC Press, Pensacola, FL, , 149-181, (2005).
Impact/Purpose:
To better understand comparative genomics between terrestrial and aquatic vertebrate, invertebrate, and plant species in order to improve our ability to extrapolate data currently derived in mammals to predict effects across aquatic phyla
Description:
The limitations surrounding application of pharmaceutical data are restricted to extrapolation of the animal and human data across phyla. Experience dictates that mammalian data are most likely to extrapolate predictably to fish and other aquatic vertebrates (e.g. Amphibia), and much less likely to extrapolate to invertebrate species, let alone plant and algae species. However, growing knowledge of comparative genomics between terrestrial and aquatic vertebrate, invertebrate, and plant species may substantially improve ability to extrapolate data currently derived in mammals to predict effects across aquatic phyla in the future.