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Integrated Science Assessment (ISA) for Lead (External Review Draft, 2023)
[NOTICE] EPA announced the release of the Integrated Science Assessment for Lead (External Review Draft, 2023) for a 60-day public comment period and CASAC review in a Federal Register Notice. The deadline for comments was extended an additional 2 weeks until Jun 13, 2023 as announced in a subsequent FRN notice.
Citation:
U.S. EPA. Integrated Science Assessment (ISA) for Lead (External Review Draft, 2023). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R‑23/061, 2023.
Impact/Purpose:
EPA is preparing to release the External Review Draft of the Integrated Science Assessment (ISA) for Lead (Pb) for public comment and peer review. The Clean Air Act (CAA) requires the United States Environmental Protection Agency (U.S. EPA) to set National Ambient Air Quality Standards (NAAQS) for criteria air pollutants, including lead (Pb), that are considered harmful to public health and the environment, and to periodically review the science upon which the NAAQS are based. When final, the ISA will represent the Agency’s latest evaluation of the scientific literature on relationships between Pb exposure and health and welfare effects.
Description:
EPA announced that an external review draft of the Integrated Science Assessment (ISA) for Lead (Pb) was made available for independent peer review and public comment. This draft ISA represents a concise synthesis and evaluation of the most policy-relevant science and will ultimately provide the scientific bases for EPA’s decision regarding whether the current standards for Pb sufficiently protect public health and the environment.
URLs/Downloads:
Front Matter, Executive Summary, and Integrative Synthesis (PDF, 149 pp, 2317 KB, about PDF)Appendix 1. Lead Source to Concentration (PDF, 88 pp, 1438 KB, about PDF)
Appendix 2. Exposure, Toxicokinetics, and Biomarkers (PDF, 164 pp, 2200 KB, about PDF)
Appendix 3. Nervous System Effects (PDF, 541 pp, 5902 KB, about PDF)
Appendix 4. Cardiovascular Effects (PDF, 173 pp, 3345 KB, about PDF)
Appendix 5. Renal Effects (PDF, 89 pp, 1632 KB, about PDF)
Appendix 6. Immune System Effects (PDF, 90 pp, 1230 KB, about PDF)
Appendix 7. Hematological Effects (PDF, 44 pp, 891 KB, about PDF)
Appendix 8. Reproductive and Developmental Effects (PDF, 266 pp, 2462 KB, about PDF)
Appendix 9. Effects on Other Organ Systems and Mortality (PDF, 166 pp, 2047 KB, about PDF)
Appendix 10. Cancer (PDF, 53 pp, 2909 KB, about PDF)
Appendix 11. Effects of Lead in Terrestrial and Aquatic Ecosystems (PDF, 257 pp, 7433 KB, about PDF)
Appendix 12. Process for Developing the Pb Integrated Science Assessment (PDF, 40 pp, 929 KB, about PDF)
FR Notice: May 15, 2023
FR Notice: Mar 31, 2023
EPA-HQ-ORD-2020-0701
Health & Environmental Research Online (HERO) Project Page
Health Assessment Workspace Collaborative (HAWC) Project Page
Air Quality Analysis Website
Peer Review Plan (PDF, NA pp, 37 KB, about PDF)
PEER REVIEW CHARGE (PDF, 5 pp, 287 KB, about PDF)
CASAC REVIEW OF THE EPA’S INTEGRATED SCIENCE ASSESSMENT (ISA) FOR LEAD (EXTERNAL REVIEW DRAFT – MARCH 2023) (PDF, 130 pp, 1556 KB, about PDF)
EPA-CASAC-23-003 RESPONSE-REV (PDF, 5 pp, 300 KB, about PDF)