Science Inventory

Peer Review for EPA’s Biologically Based Dose-Response (BBDR) Model for Perchlorate

Citation:

Peer Review for EPA’s Biologically Based Dose-Response (BBDR) Model for Perchlorate.

Impact/Purpose:

EPA is undertaking a peer review to provide a focused, objective independent peer evaluation of the draft model and its model results report. Peer review is an important component of the scientific process. The criticism, suggestions, and new ideas provided by the peer reviewers stimulate creative thought, strengthen the interpretation of the reviewed material, and confer credibility on the product. The peer review objective is to provide advice to EPA on steps that will yield a highly credible scientific product that is supported by the scientific community and a defensible perchlorate MCLG.

Description:

EPA is developing a regulation for perchlorate in drinking water. As part the regulatory process EPA must develop a Maximum Contaminant Level Goal (MCLG). FDA and EPA scientists developed a biologically based dose-response (BBDR) model to assist in deriving the MCLG. This model is designed to determine under what conditions of iodine nutrition and exposure to perchlorate across sensitive lifestages would result in low serum free and total thyroxine (hypothyroxinemia). EPA is undertaking a peer review to provide a focused, objective independent peer evaluation of the draft model and its model results report.

URLs/Downloads:

External Peer Review for EPA’s Draft Biologically Based Dose-Response (BBDR) Model and Draft BBDR Model Report for Perchlorate in Drinking Water   (PDF,NA pp, 1872 KB,  about PDF)

Federal Register Notice (10/25/2016) extension of comment period   Exit

Federal Register Notice (09/30/2016) comment external reviewers   Exit

Biologically Based Dose Response Models for the Effect of Perchlorate on Thyroid Hormones in the Infant, Breast Feeding Mother, Pregnant Mother, and Fetus   (PDF,NA pp, 3686 KB,  about PDF)

Federal Register Notice (03/01/2016) 1st nomination of reviewers   Exit

Federal Register Notice (09/30/2016) comment on BBDR Model   Exit

Federal Register Notice (06/03/2016) 2nd nomination of reviewers   Exit

Federal Register Notice (12/05/2016) Final Reviewers and Charge   Exit

Record Details:

Record Type: DOCUMENT (CRITERIA DOCUMENT)
Product Published Date: 03/29/2017
Record Last Revised: 01/31/2019
OMB Category: Highly Influential
Record ID: 311220