Science Inventory

OPPT workplan risk assessment 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8,-hexamethylcyclopenta[g]-2-benzopyran (HHCB) (CASRN 1222-05-5)


OPPT workplan risk assessment 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8,-hexamethylcyclopenta[g]-2-benzopyran (HHCB) (CASRN 1222-05-5).


EPA anticipates issuing draft risk assessments for public review and comment as they are completed. At the conclusion of the review process, if an assessment of specific uses indicates significant risk, EPA will evaluate and pursue appropriate risk reduction actions, as warranted. If an assessment indicates no significant risk, EPA will conclude its current work on assessment of those specified targeted uses of that chemical. Over time, additional chemicals will be added to the work plan as more data are developed and more chemicals screened.


HHCB (Galaxolide) is a synthetic polycyclic musk used as an ingredient in a wide range of consumer products including perfumes, cosmetics, shampoos, lotions, detergents, fabric softeners, and cleaning agents. It is one of the largest-volume chemicals of the polycyclic musks and is imported into the U.S. by 4 known importers. HHCB is considered one of the more important compounds to the fragrance industry because, as a musk, it imparts unique odor properties, has the ability to improve the fixation of fragrance compounds, and binds fragrances to fabrics. The assessment will focus on environmental risk due to release of HHCB to the aquatic and terrestrial environment from all combined uses. Human health risks have been evaluated previously and will be summarized in this assessment.


Final HHCB assessment

Peer Review Plan  (PDF, NA pp,  35  KB,  about PDF)

HHCB Response to peer review and public comments  (PDF, NA pp,  531  KB,  about PDF)

Peer review charge questions for HHCB  (PDF, NA pp,  114  KB,  about PDF)


HHCB WP RA FINAL 08_27_14.PDF  (PDF, NA pp,  1200  KB,  about PDF)

Record Details:

Product Published Date:08/28/2014
Record Last Revised:10/31/2014
OMB Category:Influential
Record ID: 245534