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IRIS Toxicological Review of Formaldehyde (Inhalation) (External Review Draft, 2010)
Citation:
U.S. EPA. IRIS Toxicological Review of Formaldehyde (Inhalation) (External Review Draft, 2010). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-10/002A, 2010.
Impact/Purpose:
The draft Toxicological Review of Formaldehyde-Inhalation Assessment provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic inhalation exposure to formaldehyde.
Description:
In June 2010, EPA released an external review draft of the formaldehyde reassessment for public review and comment. The IRIS Toxicological Review of Formaldehyde (Inhalation) provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic inhalation exposure to formaldehyde.
Then in 2014, EPA began revising its assessment to address the 2011 NAS peer review recommendations (see related links). This assessment addresses both noncancer and cancer human health effects that are relevant to assessing the risks from chronic inhalation exposure to formaldehyde. To facilitate discussion of several scientific issues pertinent to the assessment, EPA convened a public workshop held on April 30 and May 1, 2014. This workshop focused on the following three themes:
- Evidence pertaining to the influence of formaldehyde that is produced endogenously (by the body during normal biological processes) on the toxicity of inhaled formaldehyde, and implications for the health assessment;
- Mechanistic evidence relevant to formaldehyde inhalation exposure and lymphohematopoietic cancers (leukemia and lymphomas); and
- Epidemiological research examining the potential association between formaldehyde exposure and lymphohematopoietic cancers (leukemia and lymphomas).
URLs/Downloads:
Toxicological Review of Formaldehyde-Inhalation Assessment: In Support of Summary Information on the Integrated Risk Information System (IRIS) (PDF, 1043 pp, 7925 KB, about PDF)Tox Review of Formaldehyde, Volume 1: Introduction, Background, and Toxicokinetics (PDF, 112 pp, 1183 KB, about PDF)
Tox Review of Formaldehyde, Volume 2: Hazard Characterization (PDF, 570 pp, 4300 KB, about PDF)
Tox Review of Formaldehyde, Volume 3: Quantitative Assessment, Major Conclusions in the Characterization of Hazard and Dose Response, and References (PDF, 253 pp, 1606 KB, about PDF)
Tox Review of Formaldehyde, Volume 4: Appendices (PDF, 108 pp, 1067 KB, about PDF)
Charge to the NAS Panel (PDF, 2 pp, 24 KB, about PDF)
NAS: Review of EPA's Draft IRIS Assessment of Formaldehyde (Project Overview)
NAS Public Review Mtg Announcement: Jun 7-8, 2010
Press Release: EPA Releases Draft Formaldehyde Assessment Report for Peer Review and Public Comment
FR Notice: Jun 2, 2010
Press Release: Jun 1, 2010
NAS Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde (Final Report)
NAS Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde (Final Report)
Peer Review Plan (PDF, NA pp, 33 KB, about PDF)
Agency Response to Formaldehyde 2010 ERD (PDF, NA pp, 29 KB, about PDF)