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The purpose of the external peer review is to determine: a)if the proposed quantitative dose-response models have been developed using approriate statistical methods, b) whether the models have been developed using all relevant and appropriate data, and c) whether the revised protocol is superior to the current protocol and should be recommend for use at Superfund sites.

Description:

The alternative approach for estimating cancer potency from inhalation exposure to asbestos seeks to improve the methods developed by USEPA (1986). This efforts seeks to modify the the current approach for estimating cancer potency for lung cancer and mesothelioma to account for the current scientific consensus that cancer risk from asbestos depends both on mineral type and on particle size distribution. In brief, epidemiological exposure-response data for lung cancer and mesothelioma in asbestos workers are combined with estimates of the mineral type(s) and partical size distribution at each exposure location in order to estimate potency factors that are specific to a selected set of mineral type and size "bins".

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