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TECHNIQUES WITH POTENTIAL FOR HANDLING ENVIRONMENTAL SAMPLES IN CAPILLARY ELECTROPHORESIS
Brumley, W. TECHNIQUES WITH POTENTIAL FOR HANDLING ENVIRONMENTAL SAMPLES IN CAPILLARY ELECTROPHORESIS. Journal of Chromatographic Science 33(12):670-685, (1995).
An assessment of the methods for handling environmental samples prior to capillary electrophoresis (CE) is presented for both aqueous and solid matrices. Sample handling in environmental analyses is the subject of ongoing research at the Environmental Protection Agency's National Exposure Research Laboratory (Las Vegas). For aqueous matrices, both on-column and off-column techniques for preconcentration and cleanup are described. On-column techniques include field amlification and isotachophoresis. Concentration factors up to 1,000 have been reported. Cleanup techniques are also discussed. For samples from solid matrices, especially soil, both extraction/cleanup and final separation/determination are illustrated. Emphasis is placed on comparing extraction procedures with respect to speed, analyte recovery, solvent usage, and ease of interfacing with CE. Cleanup procedures and detection approaches are discussed. Prospects for future developments and suggestions for future research are presented.