Science Inventory

MICROWAVE TECHNOLOGY CHEMICAL SYNTHESIS APPLICATIONS

Citation:

Varma*, R S. MICROWAVE TECHNOLOGY CHEMICAL SYNTHESIS APPLICATIONS. Fifith, Chapter , Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons Incorporated, New York, NY, 16:538-594, (2007).

Impact/Purpose:

Information

Description:

Microwave-accelerated chemical syntheses in various solvents as well as under solvent-free conditions have witnessed an explosive growth. The technique has found widespread application predominantly exploiting the inexpensive unmodified household microwave (MW) ovens although the use of dedicated MW ewuipment has been rapidly gaining ground. Of special interest is the environmentally friendlier solventless approach that often involves exposure of neat reactions to MW irradiation or employs supported reagents on recyclable inorganic oxides or catalysts and has been adequately demonstrated in several MW-assisted condensation, deprotection, rearrangement, cyclization, reduction and oxidation reactions. The rapid one-pot preparation of heterocyclic compounds from in situ generated reactive intermediates and the general application to multi-component reactions, that are adaptable for building a library of compounds has been accomplished using this MW technique. More recently, the strategy has been extended to combinatorial chemistry and the synthesis of a newer class of solvents, ionic liquids that are essentially molten salts with barely measurable vapor pressure. The salient features of these high yield protocols namely the selectivity, esperimental ease of manipulation and the enhanced reaction rates are discussed.

URLs/Downloads:

KIRK-OTHMER ENCYCLOPEDIA OF CHEMICAL TECHNOLOGY, VOLUME 16, 5TH EDITION   Exit

Record Details:

Record Type: DOCUMENT (BOOK CHAPTER)
Product Published Date: 11/01/2005
Record Last Revised: 01/07/2010
OMB Category: Other
Record ID: 75436

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL RISK MANAGEMENT RESEARCH LABORATORY

SUSTAINABLE TECHNOLOGY DIVISION

CLEAN PROCESSES BRANCH