Science Inventory

MICROWAVES IN ORGANIC SYNTHESIS

Citation:

Varma*, R S. MICROWAVES IN ORGANIC SYNTHESIS. McGraw-Hill 2002 Yearbook of Science and Technology. McGraw-Hill Companies, New York, NY, , 223-225, (2001).

Description:

The effect of microwaves, a non-ionizing radiation, on organic reactions is described both in polar solvents and under solvent-free conditions. The special applications are highlighted in the context of solventless organic synthesis which involve microwave (MW) exposure of neat reactants (undiluted) either in presence of a catalyst or catalyzed by the surfaces of inexpensive and recyclable mineral supports such as alumina, silica, clay, or "doped" surfaces. A variety of cleavage, condensation, cyclization, oxidation and reduction reactions are exemplified including the efficient one-pot assembly of heterocyclic molecules from in situ generated intermediates such as enamines and ~-tosyloxyketones. The application of this emerging microwave technology and future outlook is summarized. The bibliography encompassing web sites information provides links to the state-of-the-art equipment available.

Record Details:

Record Type: DOCUMENT (BOOK CHAPTER)
Product Published Date: 09/15/2001
Record Last Revised: 12/22/2005
Record ID: 65860

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL RISK MANAGEMENT RESEARCH LABORATORY

SUSTAINABLE TECHNOLOGY DIVISION

CLEAN PROCESSES BRANCH