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ALDOL- AND MANNICH-TYPE REACTIONS VIA IN SITU OLEFIN MIGRATION IN IONIC LIQUID
Yang, X. F., M. Wang, R S. Varma*, AND C. J. Li. ALDOL- AND MANNICH-TYPE REACTIONS VIA IN SITU OLEFIN MIGRATION IN IONIC LIQUID. Smith, III, A.B. (ed.), ORGANIC LETTERS. American Chemical Society, Washington, DC, 5(5):657-660, (2003).
An aldol-type and a Mannich-type reaction via the cross-coupling of aldehydes and imines with allylic alcohols catalyzed by RuCl2(PPh3)3 was developed with ionic liquid as the solvent. The solvent/catalyst system could be reused for at least five times with no loss of reactivity.