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Engineering Issue Paper: Biotransformation Pathways of Dimethylarsinic (Cacodylic) Acid in the Environment
McKernan, J. Engineering Issue Paper: Biotransformation Pathways of Dimethylarsinic (Cacodylic) Acid in the Environment. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-14/219, 2015.
The U.S. Environmental Protection Agency (EPA) Engineering Issue Papers (EIPs) are a series of documents that summarize the available information on specific contaminants, selected treatment and site remediation technologies, and related issues. This EIP is intended to provide remedial project managers (RPMs), on-scene coordinators (OSCs), contractors, and other state or private remediation managers with an overview regarding the biotransformation of dimethylarsinic acid (DMA[V]). The (V) suffix in DMA(V) denotes the +5 oxidation state of arsenic.
This EIP summarizes the state of the science regarding the biotransformation of DMA(V) and was developed from peer-reviewed literature, scientific documents, EPA reports, internet sources, input from experts in the field, and other pertinent sources. This EIP includes a review of the current understanding of biologically-mediated transformation of DMA(V) and its metabolites. Given the challenges remaining in transitioning from laboratory studies to field applications, this EIP provides summary guidance for implementing currently recommended remediation strategies for DMA(V) at contaminated sites.