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Synthesis of unnatural amino acids via microwave-assisted regio-selective one-pot multi-component reactions of sulfamidates
Baig, N. AND R. Varma. Synthesis of unnatural amino acids via microwave-assisted regio-selective one-pot multi-component reactions of sulfamidates. Current Organic Chemistry. Bentham Science Publishers, Ltd., Oak Park, IL, 17(20):2323-2331, (2013).
Submitted to the Royal Society of chemistry (RSC) journal, Organic and Biomolecular Chemistry
Synthesis of triazole-based unnatural amino acids, triazole bisaminoacids and β-amino triazole has been described via stereo and regioselective one-pot multi-component reaction of sulfamidates, sodium azide, and alkynes under MW irradiation conditions. The developed method is applicable to a broad substrate scope and has significant potential for the synthesis of triazole modified unnatural amino acids.
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL RISK MANAGEMENT RESEARCH LABORATORY
SUSTAINABLE TECHNOLOGY DIVISION
CLEAN PROCESSES BRANCH